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ODN 1826
CAS No. 202668-42-6
ODN 1826( —— )
Catalog No. M36602 CAS No. 202668-42-6
ODN 1826 is a 20-mer DNA strand, a TLR9 agonist and an immunostimulant, with anti-tumor and cardioprotective effects, promoting apoptosis, and stimulating the production of NO and iNOS. ODN 1826 is a CpG DNA mimetic that can be used as an adjuvant for synthetic vaccines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameODN 1826
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NoteResearch use only, not for human use.
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Brief DescriptionODN 1826 is a 20-mer DNA strand, a TLR9 agonist and an immunostimulant, with anti-tumor and cardioprotective effects, promoting apoptosis, and stimulating the production of NO and iNOS. ODN 1826 is a CpG DNA mimetic that can be used as an adjuvant for synthetic vaccines.
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DescriptionODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’.
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In VitroWestern Blot Analysis Cell Line:RAW 264.7 Concentration:1 μg/mL Incubation Time:24 h Result:Increased the production of NO and iNOS.
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In VivoAnimal Model:Chronic vascular injury mouse models Dosage:18 nM CPG ODN Administration:s.c,three times a week for 7 weeks Result:Increased in aortic atherosclerotic plaque size compared to vehicle.Animal Model:Lewis Lung Cancer Murine Tumor ModelDosage:0.05 mg (1, 3, 5, 8, 11, 13 days) Administration:Intraperitoneal injection (i.p.)Result:Delayed tumor growth,decreased tumor weight and increased the apoptosis of tumor cells.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR | NOS
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Research Area——
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Indication——
Chemical Information
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CAS Number202668-42-6
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Formula Weight6364.1
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Molecular Formula——
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 50 mg/mL (7.86 mM; Ultrasonic)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326.?
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